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Related Concept Videos

Bone Disorders01:29

Bone Disorders

4.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Related Experiment Video

Updated: Nov 26, 2025

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults
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Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults

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[Spinal Disorders in the Oldest-Old].

Takashi Kameyama1

  • 1Department of Neurology, Chubu Rosai Hospital.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|December 9, 2020
PubMed
Summary

Adult spinal deformity, a common issue in older adults, impacts daily life and quality of life. Corrective spine surgery is emerging as a treatment for this condition, addressing postural abnormalities and motor dysfunction.

Area of Science:

  • Geriatric medicine
  • Orthopedic surgery
  • Neurology

Background:

  • Adult spinal deformity, particularly thoracolumbar hyperkyphosis, is increasingly prevalent in the aging population.
  • This condition is linked to diminished activities of daily living (ADL) and overall quality of life (QOL).
  • Spinal disorders are common in the elderly, including osteoporosis, vertebral compression fractures, diffuse idiopathic skeletal hyperostosis, and cervical spinal cord injury without bone injury.

Purpose of the Study:

  • To highlight the prevalence and impact of adult spinal deformity in the aging population.
  • To discuss the development of corrective spine surgery for thoracolumbar hyperkyphosis.
  • To emphasize the importance of recognizing spinal disorders and locomotive syndrome in elderly patients, especially those with Parkinson's disease, for effective management of motor dysfunction.

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Evaluation of Patients' Posture and Gait Profile After Lumbar Fusion Surgery by Video Rasterstereography and Treadmill Gait Analysis
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Evaluation of Patients' Posture and Gait Profile After Lumbar Fusion Surgery by Video Rasterstereography and Treadmill Gait Analysis

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Evaluation of Patients' Posture and Gait Profile After Lumbar Fusion Surgery by Video Rasterstereography and Treadmill Gait Analysis
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Main Methods:

  • Literature review and synthesis of current research on adult spinal deformity.
  • Analysis of the association between spinal deformities and patient-reported outcomes (ADL, QOL).
  • Discussion of specific spinal conditions prevalent in the aged, including Parkinson's disease-related complications and diffuse idiopathic skeletal hyperostosis.

Main Results:

  • Adult spinal deformity, especially thoracolumbar hyperkyphosis, significantly impairs ADL and QOL in the elderly.
  • Osteoporosis and vertebral compression fractures in older patients with Parkinson's disease contribute to spinal deformity and postural abnormalities.
  • Neurologists must consider locomotive syndrome, encompassing various spinal disorders, for comprehensive care of motor dysfunction in super-old patients.

Conclusions:

  • Corrective spine surgery is an evolving treatment option for adult spinal deformity.
  • Integrated management considering spinal health is crucial for maintaining mobility and function in the aging population.
  • Awareness of spinal disorders among neurologists is vital for optimizing the care of elderly patients with motor impairments.