Related Experiment Video
Updated: Nov 26, 2025
12:18
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
7.8K
[Dementia of the Oldest-Old]
1Department of Clinical Laboratory, National Center of Neurology and Psychiatry, (NCNP) National Center Hospital.
Brain and Nerve = Shinkei Kenkyu No Shinpo
|December 9, 2020
Summary
Providing comprehensive medical care for the oldest-old requires a broad perspective. Polypharmacy significantly impacts cognitive decline in older adults, with dementia linked to various neuropathologies.
Area of Science:
- Geriatrics
- Neurology
- Pathology
Background:
- Optimal medical care for the oldest-old necessitates a holistic approach.
- Polypharmacy is a critical factor influencing cognitive decline in elderly populations.
- Dementia in the oldest-old presents with diverse neuropathologic changes.
Purpose of the Study:
- To highlight the importance of a wide perspective in geriatric medical care.
- To emphasize the role of polypharmacy in cognitive decline among older adults.
- To outline the neuropathologic underpinnings of dementia in the oldest-old.
Main Methods:
- Review of current clinical practices in geriatric care.
- Analysis of the impact of polypharmacy on cognitive function.
- Examination of neuropathologic findings associated with dementia in the oldest-old.
Main Results:
- A broad perspective is essential for effective geriatric care.
- Polypharmacy is a significant contributor to cognitive decline in the elderly.
- Neuropathologies such as Alzheimer's disease, Lewy body disease, and cerebrovascular disease are common in oldest-old individuals with dementia.
Conclusions:
- Comprehensive care for the oldest-old requires attention to polypharmacy and cognitive health.
- Understanding the diverse neuropathologic causes of dementia is crucial for accurate diagnosis and treatment.
- Further research into managing polypharmacy and its effects on cognition in the oldest-old is warranted.
Related Concept Videos
01:30Dementia
378
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
378
01:15Drug Dosing: Geriatric Patients
115
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
115
01:26Alzheimer's Disease: Overview
1.2K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.2K
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
102
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
102
01:30Cognitive Development During Adulthood
552
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
552
01:22Alzheimer's Disease: Treatment
593
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
593