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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

5.8K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.3K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Related Experiment Video

Updated: Nov 26, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

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Targeting Notch in oncology: the path forward.

Samarpan Majumder1,2, Judy S Crabtree1,2, Todd E Golde3,4

  • 1Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Nature Reviews. Drug Discovery
|December 9, 2020
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Summary

Notch signalling impacts cancer growth, immunity, and stem cells, acting as both an oncogene and tumor suppressor. Ongoing research into its complex roles is paving the way for new cancer therapies.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Notch signaling is integral to cancer biology, influencing angiogenesis, tumor immunity, and cancer stem cell maintenance.
  • Notch signaling exhibits dual roles, functioning as both an oncogene and a tumor suppressor depending on the cancer type and cellular context.
  • Despite preclinical promise, developing safe and effective Notch-targeting cancer therapies remains a challenge.

Purpose of the Study:

  • To explore the multifaceted roles of Notch signaling in various cancer aspects.
  • To highlight the challenges and advancements in developing Notch-targeted therapeutics.
  • To emphasize the importance of understanding Notch signaling complexity for future drug discovery.

Main Methods:

  • Review of current literature on Notch signaling in cancer.
  • Analysis of preclinical and clinical trial data for Notch-targeting agents.
  • Investigation of Notch pathway crosstalk with other signaling cascades.

Main Results:

  • Notch signaling is implicated in key cancer processes like angiogenesis, immune evasion, and stemness.
  • The oncogenic or tumor-suppressive function of Notch varies significantly across different cancers and cell populations.
  • Current Notch-targeting agents face challenges in achieving tumor selectivity and clinical efficacy.

Conclusions:

  • A deeper understanding of Notch signaling in specific cancers and cellular contexts is crucial.
  • Interactions between Notch and other pathways offer new therapeutic targets.
  • Continued research is essential for the development of novel, effective Notch-targeted cancer treatments.