Emergence of Meningitis Caused by Nonvaccine Serotypes of Pneumococcus in Rural United States

Jessie Marks1, Guru V Bhoojhawon1, Katherine D Patrick1

  • 1Stead Family Department of Pediatrics, University of Iowa Stead Family Children's Hospital, 200 Hawkins Dr., Iowa City, Iowa 52242, USA.

Insights

Pneumococcal conjugate vaccines reduced invasive pneumococcal disease (IPD) in children. However, infections from nonvaccine Streptococcus pneumoniae serotypes, like 35B and 11A causing meningitis, have increased.

Area of Science:

  • Microbiology
  • Epidemiology
  • Vaccinology

Background:

  • Pneumococcal conjugate vaccines (PCVs) have significantly reduced invasive pneumococcal disease (IPD) in children.
  • Post-vaccine introduction, a rise in infections caused by nonvaccine Streptococcus pneumoniae serotypes has been observed.

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