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Transcatheter-Delivered Expandable Bioresorbable Polymeric Graft With Stenting Capacity Induces Vascular Regeneration
Renee Duijvelshoff1,2, Maria S Cabrera3, Bart Sanders3
1Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
JACC. Basic to Translational Science
|December 9, 2020
Abstract:
As the next step in the translation of vascular tissue engineering, this study uniquely combines transcatheter delivery and in situ tissue regeneration using a novel bioresorbable electrospun polymer graft that can be implanted minimally invasively. Once delivered inside a small-diameter vessel, the electrospun microstructure supports the vessel wall, facilitates cellular infiltration, and guides organized tissue formation.
Keywords:
BVS, bioresorbable vascular scaffold(s)ECM, extracellular matrixGPC, gel permeation chromatographyMw, weight-average molecular weightPBS, phosphate-buffered salineSEM, scanning electron microscopySMA, smooth muscle actinSMC, smooth muscle cellT-TEVG, transcatheter tissue-engineered vascular graftTE, tissue engineeringelastinregenerationtissue engineeringtranscatheter deliveryvascular graft
