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Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy

Amin Mahpour1,2, Alan C Mullen1,2,3

  • 1Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

JHEP Reports : Innovation in Hepatology
|December 9, 2020
PubMed

Keywords:
ABCA1, ATP-binding cassette transporter A1ACTA2/ɑ-SMA, α-smooth muscle actinAPO, apolipoproteinASO, antisense oligonucleotidesBDL, bile duct ligationCCA, cholangiocarcinomaCCl4, carbon tetrachlorideCOL1A1, collagen type I α 1CYP, cytochrome P450CholangiocarcinomaDANCR, differentiation antagonising non-protein coding RNADE, definitive endodermDEANR1, definitive endoderm-associated lncRNA1DIGIT, divergent to goosecoid, induced by TGF-β family signallingDILC, downregulated in liver cancer stem cellsEST, expression sequence tagEpCAM, epithelial cell adhesion moleculeFBP1, fructose-bisphosphatase 1FENDRR, foetal-lethal non-coding developmental regulatory RNAFXR, farnesoid X receptorGAS5, growth arrest-specific transcript 5H3K18ac, histone 3 lysine 18 acetylationH3K36me3, histone 3 lysine 36 trimethylationH3K4me3, histone 3 lysine 4 trimethylationHCC, hepatocellular carcinomaHEIH, high expression In HCCHNRNPA1, heterogenous nuclear protein ribonucleoprotein A1HOTAIR, HOX transcript antisense RNAHOTTIP, HOXA transcript at the distal tipHSC, hepatic stellate cellsHULC, highly upregulated in liver cancerHepatocellular carcinomaHuR, human antigen RLCSC, liver cancer stem cellLSD1, lysine-specific demethylase 1LXR, liver X receptorsLeXis, liver-expressed LXR-induced sequenceLiver cancerLiver fibrosisLiver metabolismLiver-specific lncRNAsLncLSTR, lncRNA liver-specific triglyceride regulatorMALAT1, metastasis-associated lung adenocarcinoma transcript 1MEG3, maternally expressed gene 3NAT, natural antisense transcriptNEAT1, nuclear enriched abundant transcript 1ORF, open reading framePKM2, pyruvate kinase muscle isozyme M2PPAR-α, peroxisome proliferator-activated receptor-αPRC, polycomb repressive complexRACE, rapid amplification of cDNA endsRNA Pol, RNA polymeraseS6K1, S6 kinase 1SHP, small heterodimer partnerSREBPs, steroid response binding proteinsSREs, sterol response elementsTGF-β, transforming growth factor-βTTR, transthyretinXIST, X-inactive specific transcriptZEB1, zinc finger E-box-binding homeobox 1ceRNA, competing endogenous RNAeRNA, enhancer RNAslincRNA, long intervening non-coding RNAlncRNAlncRNA, long non-coding RNAmTOR, mammalian target of rapamycinsiRNA, small interfering RNA

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