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Updated: Nov 26, 2025
A Strategy for Sensitive, Large Scale Quantitative Metabolomics
Published on: May 27, 2014
SUMMER, a shiny utility for metabolomics and multiomics exploratory research
Ling Huang1, Antonio Currais2, Maxim N Shokhirev3
1Razavi Newman Integrative Genomics and Bioinformatics Core, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.
Introduction:
Cellular metabolites are generated by a complex network of biochemical reactions. This makes interpreting changes in metabolites exceptionally challenging.
Objectives:
To develop a computational tool that integrates multiomics data at the level of reactions.
Methods:
Changes in metabolic reactions are modeled with input from transcriptomics/proteomics measurements of enzymes and metabolomic measurements of metabolites.
Results:
We developed SUMMER, which identified more relevant signals, key metabolic reactions, and relevant underlying biological pathways in a real-world case study.
Conclusion:
SUMMER performs integrative analysis for data interpretation and exploration. SUMMER is freely accessible at http://summer.salk.edu and the code is available at https://bitbucket.org/salkigc/summer .
