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Lactobacillus rhamnosus MP108: Toxicological evaluation.

Bo Zhang1, Barry Lynch2, Jian Zhao1

  • 1Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, China.

Journal of Food Science
|December 9, 2020
PubMed
Summary

Lactobacillus rhamnosus MP108, a potential probiotic, demonstrated safety in genetic toxicity and 90-day rat oral toxicity studies. This probiotic strain shows no safety concerns for use.

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Area of Science:

  • Microbiology
  • Toxicology
  • Probiotics

Background:

  • Lactobacillus rhamnosus MP108, isolated from infant feces, is developed as a potential probiotic.
  • Previous use in food suggests potential, but rigorous safety assessment is needed.

Purpose of the Study:

  • To evaluate the safety of Lactobacillus rhamnosus MP108 through comprehensive toxicological studies.
  • To provide assurance for the safe application of this specific L. rhamnosus strain.

Main Methods:

  • Conducted three genetic toxicity studies: Ames assay, in vivo mouse micronucleus, and in vivo mouse spermatocyte chromosome aberration assays.
  • Performed a 90-day oral toxicity study in Sprague-Dawley (SD) rats.
  • Reviewed general Lactobacillus spp. and specific L. rhamnosus pathogenicity and translocation data.
Keywords:
genotoxicitylactobacillus rhamnosusratsafety

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Main Results:

  • L. rhamnosus MP108 showed no genotoxicity in the Ames assay up to 5000 µg/plate.
  • No genotoxic effects were observed in vivo up to 5.6 g/kg body weight.
  • The 90-day rat study revealed no significant adverse effects at doses up to 1.5 g/kg body weight/day.

Conclusions:

  • Lactobacillus rhamnosus MP108 exhibits a strong safety profile based on conducted toxicological assessments.
  • The studies indicate no safety concerns regarding translocation or pathogenicity for this probiotic strain.
  • L. rhamnosus MP108 is confirmed safe for potential probiotic applications.