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Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay
Published on: April 5, 2019
Clinical significance of a single cerebrospinal fluid immunoglobulin band: A retrospective study
Maud Tusseau1, Estelle Cheli1, Romain Marignier2
1Hospices Civils de Lyon, Laboratoire d'immunologie, Hôpital Édouard Herriot, Lyon, France.
Background:
To demonstrate an inflammatory process in the central nervous system, the presence of at least two immunoglobulin (Ig) bands in the cerebrospinal fluid (CSF) is required. So far, the presence of a single abnormal Ig band is considered as negative.
Objective:
The objective was to assess retrospectively the significance of a single CSF Ig band in clinical practice.
Methods And Results:
Out of 10,286 CSF analyses, we retained 214 results with single Ig. An inflammatory neurological disorder was diagnosed in 41% of patients.
Conclusion:
Despite a modest sensitivity, the presence of a single CSF Ig band may be a biomarker of an inflammatory mechanism and, as such, may prompt the clinician to repeat the analysis when the clinical context remains suggestive.
