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Radiation-induced angiosarcoma: case report.

Lucas Aguiar Alencar de Oliveira¹, Antonio Fortes de Pádua Filho², Maria Adélia Medeiros E Melo²

¹Universidade Federal do Piauí, Teresina, PI, Brazil.

Einstein (Sao Paulo, Brazil)

|December 9, 2020

Summary

Radiogenic angiosarcoma of the breast is a rare cancer developing after radiation therapy. Early detection is crucial as subtle skin changes can be mistaken for benign conditions.

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Area of Science:

Oncology
Pathology
Radiology

Background:

Angiosarcoma of the breast is a rare malignancy, accounting for less than 1% of all breast tumors.
Radiogenic angiosarcoma of the breast, a secondary form, arises after radiation therapy and carries a poor prognosis.
Only 307 cases have been reported in the literature, highlighting its rarity.

Observation:

A 73-year-old woman with a history of breast-conserving treatment for right breast cancer presented with subtle pinkish skin changes.
Mammography showed benign alterations (BI-RADS 2), and initial biopsy suggested an atypical vascular lesion.
Histopathology and immunohistochemistry confirmed radiogenic angiosarcoma, positive for CD31, CD34, and C-MYC oncogene amplification.

Findings:

The case illustrates a delayed diagnosis of radiogenic angiosarcoma due to subtle initial skin manifestations.
These early signs can be misdiagnosed as benign conditions like telangiectasia.
Prompt recognition and diagnosis are vital for effective management.

Implications:

This case underscores the importance of considering radiogenic angiosarcoma in patients with a history of breast radiation therapy.
Increased clinical awareness can lead to earlier diagnosis and improved patient outcomes.
Further research into early detection methods for this rare breast cancer is warranted.