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Review article: Elobixibat: a novel treatment for chronic constipation
Lehar Khanna1, Michael Camilleri1
1Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, MN, USA.
Elobixibat, an ileal bile acid transport inhibitor, effectively treats chronic constipation by increasing colonic bile acids. This novel therapy is safe and shows promise for patients with severe constipation.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Chronic constipation can involve slow colonic transit and reduced fecal bile acid excretion.
- Increasing colonic bile acids is a novel therapeutic strategy.
- Ileal bile acid transporter inhibition can increase intraluminal bile acids.
Purpose of the Study:
- To evaluate the efficacy and safety of elobixibat, an ileal bile acid transport inhibitor, for chronic constipation.
Main Methods:
- Literature review of elobixibat.
- PubMed search for published studies.
Main Results:
- Elobixibat demonstrated efficacy in human trials (Phase 1-3 and 4).
- Increased secretory bile acids in the colon were linked to therapeutic effects.
- Elobixibat is safe, with diarrhea and abdominal pain as primary side effects.
Conclusions:
- Elobixibat is a safe and effective treatment for chronic constipation.
- This compound represents a new class of therapeutic agents for constipation.
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