[Senotherapy: Advances and new clinical perspectives]

Area of Science:

• Gerontology
• Cell Biology
• Biomedical Science

Background:

• Cellular senescence is a key driver of age-related degenerative diseases.
• Senescence involves profound cellular adaptations and a pro-inflammatory secretory phenotype.
• This phenotype contributes to tissue dysfunction and systemic aging.

Purpose of the Study:

• To review the latest advancements in senotherapy.
• To discuss the therapeutic potential of targeting senescent cells.
• To highlight recent clinical trial outcomes in senotherapy.

Main Methods:

• Literature review of senotherapy applications.
• Analysis of preclinical and clinical trial data.
• Discussion of senotherapeutic mechanisms and outcomes.

Main Results:

• Senotherapeutic agents effectively eliminate or block senescent cells.
• Targeting senescent cells prevents tissue degeneration in preclinical models.
• Early clinical trials demonstrate promising results for senotherapy.

Conclusions:

• Senotherapy represents a promising strategy to combat age-related decline.
• Eliminating senescent cells can improve healthspan and longevity.
• Further clinical investigation is warranted to validate senotherapy's efficacy in humans.