Related Experiment Video
Updated: Nov 26, 2025
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
Investigation of Allergic Sensitization Pattern in 4,203 Children in Northern China
Wei Wang1, Xian-Hui Zhang2, Lei Zhu2
1Department of Laboratory Medicine, Shanxi Provincial People's Hospital, Taiyuan, China.
Insights
Egg white and artemisia are the most common allergens in children in northern China. This study highlights key allergic sensitization patterns for improved diagnosis and prevention strategies.
Area of Science:
- Pediatric Allergy and Immunology
- Environmental Health
- Clinical Epidemiology
Background:
- Investigates allergen sensitization patterns in 4,203 children (0-12 years) in China's Shanxi region.
- Utilizes retrospective analysis of allergen-specific immunoglobulin E (sIgE) results from 2019.
- Employs enzyme ALLERGO-SORBENT testing for 19 common allergens.
Discussion:
- Nearly 50% of children with allergic diseases showed positive sIgE results.
- Egg white (18.63%) and artemisia (14.47%) were the most prevalent allergens.
- Significant age-related differences in food and aeroallergen sensitization were observed (p < 0.05).
Key Insights:
- Egg white and artemisia identified as primary allergens in Northern Chinese children.
- Over 50% of sensitized children reacted to multiple allergens.
- Children over 3 years old exhibited a significantly higher sensitization rate compared to younger children (p < 0.05).
Outlook:
- Provides crucial epidemiological data for understanding regional allergic disease burden.
- Informs targeted diagnosis and prevention strategies for pediatric allergic conditions.
- Highlights the need for age-specific allergen screening and management protocols.
Objective:
The objective of this study is to investigate the allergen sensitization pattern among 4,203 children in the Shanxi region of China and to provide guidance for diagnosis and prevention of allergic diseases.
Methods:
A retrospective analysis was conducted on the allergen-specific immunoglobulin E (sIgE) results of 4,203 children aged 0-12 years from January to December in 2019. SIgE antibodies to 19 allergens in the serum sample were detected by enzyme ALLERGO-SORBENT testing.
Results:
In total, 49.70% (2,089/4,203) of children with allergic diseases were positive for sIgE, and the top 5 allergens were egg white 18.63% (783/4,203), artemisia 14.47% (608/4,203), milk 13.04% (548/4,203), ragweed 8.66% (364/4,203), and poplar/willow/elm 8.52% (358/4,203). Significant differences in the positive rate of food allergens and aeroallergens in different ages were found (p < 0.05). 50.98% (1,065/2,089) patients were sensitive to 2 or more allergens. The high sensitization rate in the >3-year group was significantly higher than the ≤3-year group (p < 0.05).
Conclusion:
Egg white and artemisia are the most common allergens in children in northern China. This study provides allergic sensitization pattern of children and clinical epidemiological data in the region.
