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Updated: Nov 26, 2025
15:26
3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
Published on: May 19, 2015
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Late onset multiple sclerosis is associated with more severe ventricle expansion
Dejan Jakimovski1, Dora Dujmic1, Jesper Hagemeier1
1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Multiple Sclerosis and Related Disorders
|December 10, 2020
Summary
Late-onset multiple sclerosis (LOMS) patients show greater brain atrophy and ventricle expansion compared to adult-onset MS patients. This indicates a potentially more aggressive disease course in LOMS.
Area of Science:
- Neurology
- Radiology
- Neuroimmunology
Background:
- Late-onset multiple sclerosis (LOMS) is linked to faster disability progression than adult-onset MS (PwAOMS).
- Brain atrophy differences between LOMS and PwAOMS are not well understood.
Purpose of the Study:
- To compare MRI-derived brain atrophy rates in persons with LOMS (PwLOMS) against age- and disease duration-matched persons with adult-onset MS (PwAOMS).
Main Methods:
- 870 individuals with MS (290 PwLOMS, 290 age-matched PwAOMS, 290 disease duration-matched PwAOMS) and 150 healthy controls (HCs) were studied over 3-5 years.
- T2-lesion volume (LV), lateral ventricular volume (LVV), and whole brain volume (WBV) were measured using MRI.
- Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Severity Score (MSSS) were assessed.
Main Results:
- PwLOMS exhibited significantly higher baseline and follow-up MSSS compared to both PwAOMS groups (p<0.026).
- PwLOMS showed significantly greater percent LVV change (14.3% vs. 9.3%, p=0.001) and annualized LVV change (4.1% vs. 1.6%, p<0.001) versus age-matched PwAOMS.
- All persons with MS had greater WBV loss and LVV expansion than HCs.
Conclusions:
- Persons with LOMS experience greater ventricle expansion compared to persons with adult-onset MS.
- Higher MSSS in PwLOMS suggests a more severe disease course.
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