Related Experiment Video

Updated: Nov 26, 2025

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

4.8K

The Role of β-Arrestins in Regulating Stem Cell Phenotypes in Normal and Tumorigenic Cells

Georgios Kallifatidis1,2,3, Kenza Mamouni2,3, Bal L Lokeshwar2,3

  • 1Department of Biological Sciences, Augusta University, Augusta, GA 30912, USA.

International Journal of Molecular Sciences
|December 10, 2020
PubMed

Insights

Beta-arrestins (ARRBs) regulate stem cell maintenance through complex signaling pathways. This review explores their crucial, yet challenging, roles in normal and malignant stem cells, offering insights for targeted cancer therapies.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Beta-arrestins (ARRBs) are scaffold proteins involved in G-protein-coupled receptor signaling.
  • ARRB1 and ARRB2 exhibit opposing functions in various signaling cascades.
  • Emerging evidence links ARRBs to stem cell maintenance, but their precise roles are complex.

Purpose of the Study:

  • To review the function of ARRBs in stem cell biology.
  • To discuss ARRB regulation of signaling pathways in normal and malignant stem cells.
  • To explore therapeutic targeting of ARRBs in cancer.

Main Methods:

  • Literature review of existing studies on ARRBs and stem cell biology.
  • Analysis of signaling pathways regulated by ARRBs in stem cells.
  • Examination of ARRB roles in normal versus malignant stem cell populations.

Main Results:

  • ARRBs play a critical role in stem cell maintenance, with complex and context-dependent functions.
  • ARRB signaling pathways are implicated in both normal stem cell characteristics and malignant transformations.
  • Targeting ARRBs presents therapeutic potential but faces challenges due to their ubiquitous functions.

Conclusions:

  • ARRBs are key regulators of stem cell signaling, impacting both normal homeostasis and disease states.
  • Understanding ARRB functions is crucial for developing selective cancer therapies.
  • Specific targeting of ARRBs shows promise, particularly in myeloproliferative neoplasms.
Keywords:
cancer stem cellsself-renewalstem cell phenotypeβ-arrestin1 (ARRB1)β-arrestin2 (ARRB2)

More Related Videos

Flow Cytometric Detection of Newly-formed Breast Cancer Stem Cell-like Cells After Apoptosis Reversal11:21

Flow Cytometric Detection of Newly-formed Breast Cancer Stem Cell-like Cells After Apoptosis Reversal

Published on: January 26, 2019

10.2K
De Novo Generation of Somatic Stem Cells by YAP/TAZ13:05

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Published on: May 7, 2018

9.4K

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
37.5K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.3K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.5K
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.8K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
3.9K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.9K