Related Experiment Video

Updated: Nov 26, 2025

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

16.4K

Is being born in spring significantly associated with early-onset bipolar affective disorder? A case-control study

Meng-Qi Wang1, Yu Hao1, Ran-Ran Wang1

  • 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing, China.

Chronobiology International
|December 10, 2020
PubMed

Insights

Early-onset bipolar affective disorder (BAD) in young adults is linked to birth season. Patients with BAD were more likely to be born in spring compared to other seasons, suggesting potential implications for prevention.

Area of Science:

  • Psychiatry
  • Epidemiology
  • Chronobiology

Background:

  • Limited research exists on the association between birth season and early-onset bipolar affective disorder (BAD).
  • Understanding seasonal birth patterns may offer insights into the etiology of early-onset BAD.

Purpose of the Study:

  • To investigate the relationship between season of birth and early-onset BAD in young adults.
  • To compare birth season distributions between patients with early-onset BAD and matched controls.

Main Methods:

  • A case-control study involving 957 patients with early-onset BAD (<25 years) from the North China Plain.
  • Sex- and age-matched controls were recruited from universities and schools.
  • Statistical analyses included chi-square tests and binary logistic regression, adjusting for age and sex.

Main Results:

  • Early-onset BAD patients exhibited a significantly higher likelihood of being born in spring compared to other seasons.
  • When spring was the reference season, patients with BAD had lower odds ratios for birth in other seasons.
  • A significant association was found between birth season and the development of early-onset BAD.

Conclusions:

  • Birth season is associated with early-onset bipolar affective disorder.
  • Individuals diagnosed with early-onset BAD are more prone to being born during the spring season.
  • These findings may inform future strategies for disease prevention and research directions in bipolar disorder.

Keywords:
Birthbipolar disorderearly-onsetseason

More Related Videos

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.9K
Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.2K

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
411
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
281
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
317
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.1K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
784
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
1.0K