Related Experiment Video

Updated: Nov 26, 2025

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

15.7K

Long-Term Prognosis of Moderate to Severe Coronary Artery Calcification in Patients Undergoing Percutaneous Coronary

Sida Jia1, Jianxin Li1, Ce Zhang1

  • 1Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences.

Circulation Journal : Official Journal of the Japanese Circulation Society
|December 10, 2020
PubMed

Insights

Moderate to severe coronary artery calcification (CAC) is linked to worse outcomes after percutaneous coronary intervention (PCI). This large study confirms that severe CAC increases the risk of major adverse cardiovascular events (MACE) in these patients.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Vascular Medicine

Background:

  • Coronary artery calcification (CAC) severity is known to predict adverse outcomes in patients undergoing percutaneous coronary intervention (PCI).
  • Previous studies on this topic have been limited by small sample sizes and short follow-up periods.
  • A large-scale investigation is needed to clarify the association between CAC severity and long-term clinical outcomes in PCI patients.

Purpose of the Study:

  • To evaluate the association between the severity of coronary artery calcification (CAC) and long-term clinical outcomes in a large cohort of patients undergoing percutaneous coronary intervention (PCI).

Main Methods:

  • A prospective observational study enrolled 10,068 consecutive patients undergoing PCI.
  • Patients were categorized into none/mild CAC or moderate/severe CAC groups based on visual assessment of coronary angiography.
  • Major adverse cardiovascular events (MACE), including death, myocardial infarction, and revascularization, were assessed at 5 years.

Main Results:

  • Moderate/severe CAC was present in 18.3% of patients.
  • Patients with moderate/severe CAC exhibited a significantly higher rate of 5-year unplanned revascularization (15.2% vs. 13.2%) and MACE (20.7% vs. 17.9%).
  • After propensity score matching, moderate/severe CAC remained associated with increased 5-year unplanned revascularization and was independently linked to a higher risk of 2-year unplanned target vessel revascularization and MACE.

Conclusions:

  • Moderate to severe coronary calcification is associated with an increased risk of major adverse cardiovascular events (MACE) in patients undergoing percutaneous coronary intervention (PCI).
  • The findings highlight the importance of assessing CAC severity for risk stratification in PCI patients.
  • Further research may explore specific management strategies for patients with severe CAC undergoing PCI.
Abstract

Keywords:
CalcificationCoronary artery diseasePercutaneous coronary intervention

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.6K
Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection06:57

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

1.3K

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
227
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
131
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
106
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
578
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
97
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
125