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Related Experiment Videos

Interstitial radiation in recurrent malignant gliomas.

P W Hitchon1, S K Jani, J C VanGilder

  • 1Division of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City.

Applied Neurophysiology
|January 1, 1987
PubMed
Summary

Implanted radioactive iodine-125 (125I) seeds offer a treatment option for recurrent supratentorial gliomas. This brachytherapy approach showed promising results, with CT scans indicating tumor necrosis and some patients remaining alive.

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Recurrent supratentorial gliomas pose significant treatment challenges.
  • Interstitial brachytherapy is an option for managing recurrent brain tumors.

Purpose of the Study:

  • To evaluate the efficacy of implanted iodine-125 (125I) seeds for recurrent supratentorial gliomas.
  • To assess treatment outcomes, including tumor response and patient survival.

Main Methods:

  • Twelve patients with recurrent supratentorial gliomas underwent interstitial brachytherapy using 125I seeds.
  • Techniques included craniotomy for volume implantation and stereotactic implantation with varying seed activities.
  • Radiation doses ranged from 5,500 to 27,000 cGy.

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Main Results:

  • Sequential CT scans demonstrated progressive attenuation in enhancing areas, suggesting tumor necrosis.
  • The mean survival was 23 weeks and the median survival was 22 weeks.
  • Four of the most recent patients treated were still alive at the time of reporting.

Conclusions:

  • Implanted 125I seeds can induce tumor necrosis in recurrent supratentorial gliomas.
  • Interstitial brachytherapy with 125I seeds represents a viable treatment modality for select patients.
  • Further investigation into optimizing brachytherapy techniques for glioma treatment is warranted.