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Related Experiment Video

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Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

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Published on: December 3, 2017

New laboratory predictive tools in deep neck space infections.

Maria Luisa Fiorella¹, Paolo Greco¹, Luigi Maria Madami¹

¹Unit of Otorhinolaryngology, Department of Biomedical Sciences, Neurosciences and Sense Organs, University of Bari, Italy.

Acta Otorhinolaryngologica Italica : Organo Ufficiale Della Societa Italiana Di Otorinolaringologia E Chirurgia Cervico-Facciale

|December 10, 2020

Summary

The Laboratory Risk Indicator for Necrotizing fasciitis (LRINEC) and neutrophil to lymphocyte ratio (NLR) can help predict severe complications in deep neck space infections (DNSIs). These simple lab tests may aid early diagnosis of necrotizing fasciitis and systemic involvement.

Keywords:

LRINEC NLR neck necrotizing fasciitis sepsis

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Area of Science:

Infectious Diseases
Surgical Pathology
Diagnostic Laboratory Medicine

Background:

Deep neck space infections (DNSIs) are serious conditions requiring prompt management.
Necrotizing and septic complications of DNSIs are rare but life-threatening.
Clinical examination for DNSIs has limited sensitivity, and instrumental diagnosis can delay treatment.

Purpose of the Study:

To evaluate the utility of the Laboratory Risk Indicator for Necrotizing fasciitis (LRINEC) and neutrophil to lymphocyte ratio (NLR) in predicting severe DNSIs.
To identify rapid laboratory markers for distinguishing necrotizing complications and systemic septic involvement in DNSIs.

Main Methods:

A retrospective observational cohort study included 118 patients surgically treated for DNSIs.
LRINEC scores, NLR values, and the product of LRINEC x NLR were calculated for all patients.
Statistical analysis was performed to assess the predictive value of these laboratory markers.

Main Results:

The study found that LRINEC and NLR scores may be useful in the early diagnosis of DNSIs.
These laboratory indicators showed potential in predicting the risk of necrotizing fasciitis.
The scores also indicated utility in identifying patients with systemic septic involvement.

Conclusions:

LRINEC and NLR show promise as readily available tools for early risk stratification in DNSIs.
Further research with larger patient cohorts is recommended to enhance the sensitivity and specificity of these predictive markers.
These findings may contribute to improved management strategies for severe deep neck space infections.