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Safety Considerations in Cannabinoid-Based Medicine.

Sven Gottschling1, Oyedeji Ayonrinde2, Arun Bhaskar3

  • 1Universitätsklinikum des Saarlandes, Homburg (Saar), Germany.

International Journal of General Medicine
|December 10, 2020
PubMed
Summary

Cannabinoid medicines, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), have potential therapeutic uses but require careful safety assessment. Dizziness and fatigue are common side effects, and risks like drug interactions necessitate individualized patient evaluation.

Keywords:
cannabidiolcannabinoidcannabissafetyΔ9-tetrahydrocannabinol

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Area of Science:

  • Pharmacology and Therapeutics
  • Clinical Safety Research
  • Cannabinoid Medicine

Background:

  • Cannabinoids are increasingly recognized for therapeutic potential, yet their safety profiles are less understood than their efficacy.
  • Assessing cannabinoid medicine safety is complex due to recreational use confusion, varied study designs, and administration methods.

Purpose of the Study:

  • To clarify the safety profiles of cannabinoid-based medicines using clinical evidence.
  • To identify knowledge gaps and areas for future research in cannabinoid safety.

Main Methods:

  • Review of clinical studies on registered cannabinoid products.
  • Focus on medical and clinical safety data for Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD).

Main Results:

  • Dizziness and fatigue are common adverse events with THC and combined THC/CBD treatments.
  • THC can cause cognitive and psychomotor impairment; CBD may mitigate THC's psychotropic effects.
  • Oral administration is preferred over smoking due to potential carcinogens; drug interactions and contraindications exist.

Conclusions:

  • Cannabinoid medicines, like all pharmaceuticals, carry safety risks that must be weighed against therapeutic benefits.
  • Individual patient assessment and evidence-based decision-making are crucial for prescribing cannabinoid therapies.
  • Further research is needed to fully elucidate the safety of cannabinoid-based medicines.