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MicroRNA-361-3p Inhibit the Progression of Lymphoma by the Wnt/β-Catenin Signaling Pathway

Hui Zhou1, Huifeng Tang1, Ning Li1

  • 1Department of Hematology and Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, People's Republic of China.

Cancer Management and Research
|December 10, 2020
PubMed
Abstract

Insights

MicroRNA miR-361-3p inhibits lymphoma development by targeting Wnt10A and suppressing the Wnt/β-catenin pathway. This microRNA holds promise as a therapeutic target for lymphoma treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) play a role in lymphoma pathogenesis.
  • The specific function of miR-361-3p in lymphoma remains largely uncharacterized.
  • Previous studies suggest miR-361-3p exhibits tumor-suppressive properties.

Purpose of the Study:

  • To investigate the inhibitory effect of miR-361-3p on lymphoma development.
  • To elucidate the underlying molecular mechanisms of miR-361-3p in lymphoma.

Main Methods:

  • Functional analysis of miR-361-3p in transfected Raji cells and stable miR-361-3p transgenic cells.
  • Micro-gene network analysis to assess gene expression profiles.
  • Bioinformatic and mechanistic studies to identify miR-361-3p targets.

Main Results:

  • miR-361-3p expression is downregulated in lymphoma cell lines.
  • miR-361-3p significantly inhibits lymphoma cell proliferation and migration.
  • miR-361-3p suppresses the Wnt/β-catenin signaling pathway.
  • Wnt10A identified as a direct target of miR-361-3p.
  • Restoration of Wnt10A partially reverses the anti-lymphoma effects of miR-361-3p.

Conclusions:

  • miR-361-3p exerts tumor-inhibitory effects in lymphoma by targeting Wnt10A and inhibiting the Wnt/β-catenin pathway.
  • The miR-361-3p/Wnt10A axis represents a potential therapeutic target for lymphoma.
Keywords:
WntlymphomamiRNApathwaytumor suppressor

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