Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ethics in Research01:56

Ethics in Research

25.1K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
25.1K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

272
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
272
Ethics and Bioethics01:22

Ethics and Bioethics

2.1K
Ethics is a philosophical study of moral actions. Ethics attempts to determine what is valuable for individuals and society. It examines the rational justification of moral judgments and analyzes what is morally just, fair, and right. Bioethics is a sub-discipline of applied ethics that analyzes the philosophical, social, and legal issues in life sciences and medicine. Ethical theories serve as a foundation for decision-making and represent the viewpoints from which people seek direction. They...
2.1K
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

64
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
64
Ethical Standards II01:23

Ethical Standards II

1.1K
Ethical standards are the backbone of nursing practice, guiding nurses as they interact with patients, families, and colleagues. These standards are crucial for providing safe, empathetic care centered on the patient's needs.
Nurses are entrusted with upholding various ethical principles and standards. Nurses forge solid therapeutic relationships using trust, empathy, autonomy, confidentiality, and professional competence.
Confidentiality is crucial, embodying respect for individual privacy...
1.1K
Ethical Issues01:27

Ethical Issues

1.6K
Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The United States Withdrawal From the World Health Organization: Implications and Challenges.

International journal of health policy and management·2025
Same author

U.S. Physicians' Views on E-Cigarette Risks and Benefits to Adults Who Smoke Versus Young People Who Do Not Smoke.

AJPM focus·2025
Same author

The Social Disvalue Misconception in Clinical Research.

The American journal of bioethics : AJOB·2025
Same author

Managing infectious aerosols to counter engineered pandemics: Current recommendations and future research.

Risk analysis : an official publication of the Society for Risk Analysis·2025
Same author

Assessing the risks of current COVID-19 challenge trials systematically.

Vaccine·2025
Same author

Ethics & utility of controlled human infection studies (CHIS) in low- & middle-income countries.

The Indian journal of medical research·2024

Related Experiment Video

Updated: Nov 26, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.2K

Is There an Ethical Upper Limit on Risks to Study Participants?

Nir Eyal1

  • 1Center for Population-Level Bioethics, Department of Philosophy, Rutgers University and Department of Health Behavior, Society and Policy, Rutgers School of Public Health.

Public Health Ethics
|December 10, 2020
PubMed
Summary

This study argues that no risk to research participants is too great, regardless of a study's societal value. The ethical considerations of research risks are explored in depth.

More Related Videos

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

11.9K
Use of Galvanic Skin Responses, Salivary Biomarkers, and Self-reports to Assess Undergraduate Student Performance During a Laboratory Exam Activity
07:32

Use of Galvanic Skin Responses, Salivary Biomarkers, and Self-reports to Assess Undergraduate Student Performance During a Laboratory Exam Activity

Published on: February 10, 2016

9.6K

Related Experiment Videos

Last Updated: Nov 26, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.2K
Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

11.9K
Use of Galvanic Skin Responses, Salivary Biomarkers, and Self-reports to Assess Undergraduate Student Performance During a Laboratory Exam Activity
07:32

Use of Galvanic Skin Responses, Salivary Biomarkers, and Self-reports to Assess Undergraduate Student Performance During a Laboratory Exam Activity

Published on: February 10, 2016

9.6K

Area of Science:

  • Bioethics
  • Clinical Research Ethics
  • Participant Safety

Background:

  • Societal benefit of research is often weighed against participant risk.
  • Determining acceptable risk levels in clinical studies is a complex ethical challenge.
  • Existing ethical frameworks grapple with the balance between scientific advancement and individual protection.

Purpose of the Study:

  • To critically examine the ethical permissibility of participant risks in research.
  • To challenge the notion that certain risks are inherently unacceptable, irrespective of study value.
  • To explore the philosophical underpinnings of risk assessment in human subjects research.

Main Methods:

  • Philosophical inquiry into ethical principles.
  • Analysis of historical and contemporary research ethics debates.
  • Review of regulatory guidelines and ethical theories.

Main Results:

  • The article posits that no risk is inherently 'too much' if the study's potential societal benefit is sufficiently high.
  • It argues against absolute prohibitions on certain research risks.
  • The value of knowledge gained can, in principle, justify significant participant risks.

Conclusions:

  • Ethical evaluation of research risks must be context-dependent and consider potential societal gains.
  • Absolute ethical barriers to research based solely on risk level are not justifiable.
  • A nuanced approach prioritizing potential societal benefit is advocated for in research ethics.