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Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
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Intrauterine growth restriction: screening and diagnosis using animal models
Fernando Felicioni1, Thaís Garcia Santos1, Thaís de Mérici Domingues E Paula1
1Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Animal Reproduction
|December 10, 2020
Summary
Intrauterine growth restriction (IUGR) is a complex condition diagnosed by assessing size and weight. Animal models aid in screening and diagnosing IUGR, a condition linked to adult-onset diseases.
Area of Science:
- Reproductive biology
- Developmental biology
- Perinatology
Background:
- Intrauterine growth restriction (IUGR) is a multifactorial condition with significant health implications.
- Causes include maternal malnutrition, multiple gestation, substance abuse, and infections.
- IUGR diagnosis is challenging due to masking manifestations and lack of effective treatment.
Purpose of the Study:
- To review the contribution of animal models to the biological screening and diagnosis of IUGR.
- To highlight the importance of IUGR given its high prevalence, especially in developing countries.
Main Methods:
- Review of existing literature on animal models for IUGR.
- Discussion of diagnostic challenges and screening methodologies.
Main Results:
- Animal models offer valuable insights into the biological mechanisms of IUGR.
- These models facilitate the development of screening and diagnostic tools.
Conclusions:
- Animal models are crucial for understanding and diagnosing IUGR.
- Early diagnosis and management are vital due to IUGR's link to adult pathologies like diabetes and hypertension.
