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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Data sets on human histone interaction networks.

Yunhui Peng1, Yaroslav Markov1,2, Alexander Goncearenco1,3

  • 1National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, United States.

Data in Brief
|December 10, 2020
PubMed
Summary
This summary is machine-generated.

This study maps human histone interactomes, revealing complex protein, domain, and residue interaction networks. These comprehensive histone interaction datasets are crucial for understanding cellular processes.

Keywords:
Histone interactionHistone variantInteraction networkInteractomeNucleosome interaction

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genomics

Background:

  • Histones are fundamental proteins that package DNA into nucleosomes.
  • Understanding histone interactions is key to deciphering gene regulation and cellular function.
  • Existing interactome data may lack comprehensive coverage of human histone networks.

Purpose of the Study:

  • To present a comprehensive dataset of human histone interactomes.
  • To map histone/nucleosome interaction networks at multiple granularities.
  • To provide accessible data for further research.

Main Methods:

  • Integration of data from structural, chemical cross-linking, and high-throughput studies.
  • Analysis of histone interactions at protein, domain, and residue levels.
  • Generation of Cytoscape session files for network visualization.

Main Results:

  • A comprehensive mapping of human histone interaction networks.
  • Detailed representation of interactions across different molecular levels.
  • Availability of interactive network data.

Conclusions:

  • The presented data offers a valuable resource for studying histone biology.
  • The comprehensive interactome facilitates research into epigenetics and chromatin structure.
  • Open access to data promotes further scientific discovery.