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Updated: Nov 26, 2025

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

Risk stratification in primary sclerosing cholangitis.

Giacomo Mulinacci^1,2, Laura Cristoferi^1,2, Andrea Palermo^1,2

¹Division of Gastroenterology, Department of Medicine and Surgery, Center for Autoimmune Liver Diseases, University of Milan Bicocca, Milan, Italy.

Minerva Gastroenterology

|December 10, 2020

Summary

Primary sclerosing cholangitis (PSC) is a chronic liver disease with unpredictable progression. New approaches using genomics, imaging, and multiomics are needed for better patient stratification and treatment.

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Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

Area of Science:

Hepatology
Gastroenterology
Chronic Liver Disease Research

Background:

Primary sclerosing cholangitis (PSC) is a chronic liver disease with a heterogeneous progression rate.
It affects young patients and carries a high risk of end-stage liver disease and hepatobiliary cancer.
Current prognostic models using clinical, lab, radiological, and histological data have limited predictive performance.

Purpose of the Study:

To highlight the need for advanced strategies in primary sclerosing cholangitis research.
To emphasize the importance of accurate disease course prediction for clinical practice and trial design.
To advocate for the development of stratified medicine in PSC.

Main Methods:

Review of current challenges in predicting PSC progression.
Discussion of emerging technologies like whole genome sequencing and digital innovation.
Proposal for developing well-phenotyped cohorts with longitudinal follow-up.

Main Results:

Existing models for predicting PSC outcomes show limited performance.
There is a critical need for improved methods to stratify patients based on disease trajectory.
Multiomics platforms and advanced imaging offer potential for biomarker discovery.

Conclusions:

Stratified medicine approaches are crucial for advancing PSC patient care.
Future research should focus on well-characterized patient cohorts, novel imaging, and multiomics.
These advancements are essential for improving prognosis and therapeutic strategies in PSC.