Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

64
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
64
Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

733
The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
733
Methods of Documentation II: POMR01:26

Methods of Documentation II: POMR

1.2K
The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.
1.2K
Assessment of the Cardiovascular System I: Subjective Data01:23

Assessment of the Cardiovascular System I: Subjective Data

605
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
605
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

134
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
134

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient Perceptions on the Use of Artificial Intelligence in Creating Clinical Research Documents: Survey Study.

JMIR AI·2026
Same author

Overall Survival With Palbociclib and Aromatase Inhibitor Versus Aromatase Inhibitor Alone in Older Patients With HR+/HER2- Metastatic Breast Cancer.

Cancer medicine·2025
Same author

Data science in pharmaceutical R&D: the DISRUPT-DS industry roundtable.

Nature reviews. Drug discovery·2024
Same author

Accelerating drug development at Bristol Myers Squibb through innovation.

Drug discovery today·2024
Same author

New Benchmarks on Protocol Amendment Practices, Trends and their Impact on Clinical Trial Performance.

Therapeutic innovation & regulatory science·2024
Same author

Data-driven strategies for increasing patient diversity in Bristol Myers Squibb-sponsored US oncology clinical trials.

Clinical trials (London, England)·2023

Related Experiment Video

Updated: Nov 26, 2025

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
08:42

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

Published on: July 31, 2017

8.5K

Assessing Patient Participation Burden Based on Protocol Design Characteristics.

Kenneth Getz1, Venkat Sethuraman2, Jessica Rine2

  • 1The Center for the Study of Drug Development, Tufts University School of Medicine, 75 Kneeland Street, Boston, 021111, MA, USA. kenneth.getz@tufts.edu.

Therapeutic Innovation & Regulatory Science
|December 10, 2020
PubMed
Summary

Patient burden in clinical trials significantly impacts study performance. Higher patient burden, measured by perceived procedure difficulty, correlates with increased screen failures and longer trial durations, suggesting a need for optimized protocol design.

Keywords:
patient participation burdenprotocol design complexityprotocol design optimizationstudy volunteer burden

More Related Videos

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
06:16

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

4.1K
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

8.6K

Related Experiment Videos

Last Updated: Nov 26, 2025

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
08:42

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

Published on: July 31, 2017

8.5K
Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
06:16

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

4.1K
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

8.6K

Area of Science:

  • Clinical research methodology
  • Patient-centric trial design

Background:

  • Limited research quantifies patient burden in clinical trials.
  • Existing studies focus on site burden, neglecting participant experience.
  • Complex clinical trial protocols increase patient burden.

Purpose of the Study:

  • To quantify patient burden in clinical trials.
  • To assess the relationship between patient burden and clinical trial performance.
  • To identify factors contributing to patient burden.

Main Methods:

  • Cross-sectional pilot study with nearly 600 patients via online survey.
  • Patients rated perceived burden of 60 common protocol procedures.
  • Analysis of associations between patient burden and 137 protocol performance measures.

Main Results:

  • Significant positive associations found between patient burden and protocol design/performance.
  • Increased study visits and longer study conduct duration strongly correlated with patient burden.
  • Composite patient burden measure linked to trial efficiency.

Conclusions:

  • Patient burden is a critical factor influencing clinical trial outcomes.
  • Optimizing protocol design to reduce patient burden can improve engagement and performance.
  • Study suggests a novel approach to enhance clinical trial efficiency and patient experience.