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Light Pollution and Cancer.

William H Walker1, Jacob R Bumgarner1, James C Walton1

  • 1Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.

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|December 11, 2020
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Summary
This summary is machine-generated.

Artificial light at night (ALAN) disrupts the body's natural circadian rhythms, increasing risks for cancer and other disorders. Maintaining dark nights is crucial for health and mitigating these risks.

Keywords:
cancercell cyclecircadian rhythmsclock geneslight at night

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Area of Science:

  • Chronobiology
  • Molecular Biology
  • Cancer Research

Background:

  • Artificial light at night (ALAN) is prevalent in industrialized nations.
  • ALAN disrupts circadian organization of physiology and behavior.
  • Disrupted circadian rhythms are linked to cancer, metabolic, and mood disorders.

Purpose of the Study:

  • To review the molecular circadian clock system.
  • To explain the link between core clock genes, cell cycle, and oncogenesis.
  • To discuss the clinical implications of disrupted circadian rhythms on cancer.

Main Methods:

  • Literature review of molecular circadian clock mechanisms.
  • Analysis of the relationship between clock genes and the cell cycle.
  • Examination of scientific literature on ALAN and cancer incidence.

Main Results:

  • Core clock genes are interconnected with the cell cycle and play a role in oncogenesis.
  • Disrupted circadian rhythms due to ALAN have significant clinical implications for cancer.
  • Foundational science demonstrates a link between light at night and cancer development.

Conclusions:

  • Maintaining a clear distinction between bright days and dark nights is vital for health.
  • Strategies for mitigating disrupted circadian rhythms can improve health outcomes.
  • Understanding the impact of ALAN on circadian biology is essential for public health.