Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

9.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.2K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

3.8K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.1K
Cancer Vaccines01:30

Cancer Vaccines

665
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
665
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.6K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.6K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.5K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mature-Stage <i>Eisenia fetida</i> Proteins Suppress Macrophage Inflammation via NF-κB and MAPK Pathways.

International journal of molecular sciences·2026
Same author

Fondaparinux attenuates methotrexate-induced hepatotoxicity by regulating coagulation, endothelial dysfunction, and inflammatory signaling via the TLR4/NLRP3 and NF-κB/IL-1β/MCP-1 pathways.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same author

Exploring the Association of Genetic Determinants of SIRT1, MTHFR, and MIR146A Gene Polymorphism with the Ischemic Stroke Predisposition: A Case Control Study.

Cellular and molecular neurobiology·2026
Same author

Molecular mechanism of anticancer activity of selected coastal marsh plants from Saudi Arabia.

3 Biotech·2026
Same author

Hermetia illucens (Black Soldier Fly) Larvae Powder Restores Growth and Immune Function in a Rat Model of Malnutrition.

Chemistry & biodiversity·2026
Same author

Clinical exome sequencing identifies novel gene variants associated with ischemic stroke in the Saudi Tabuk population.

Frontiers in human neuroscience·2026

Related Experiment Video

Updated: Nov 26, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.5K

Prostate cancer and therapeutic challenges.

Yousef MohammedRabaa Hawsawi1,2, Samar Abdullah Zailaie3, Atif Abdulwahab A Oyouni4

  • 1Saudi Human Genome Program-Jeddah Satellite Laboratory, Research Center, King Faisal Specialist Hospital and Research Center, MBC-J04, P.O. Box 40047, Jeddah, 21499, Kingdom of Saudi Arabia. hyousef@kfshrc.edu.sa.

Journal of Biological Research (Thessalonike, Greece)
|December 11, 2020
PubMed
Summary

This review details how androgens and their receptors influence prostate cancer (PC) cell death. Understanding these roles is key to overcoming resistance to hormone therapies for advanced PC.

Keywords:
Androgen receptorAndrogensAnti-androgen therapyHeat-shock proteinProstate cancer

More Related Videos

A New Technique for Treating Low-risk Prostate Cancer&#8212;Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

352
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.7K

Related Experiment Videos

Last Updated: Nov 26, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.5K
A New Technique for Treating Low-risk Prostate Cancer&#8212;Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

352
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.7K

Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Biology

Background:

  • Prostate cancer (PC) is a leading global cancer in men, with rising incidence in Saudi Arabia.
  • Androgens, androgen receptors, and heat-shock proteins are crucial in PC development and progression.
  • Hormone-deprivation therapy is standard for metastatic PC, but resistance is a significant clinical challenge.

Purpose of the Study:

  • To elucidate the mechanisms by which androgens, androgen receptors, and sex steroid hormones induce apoptosis in prostate cancer.
  • To provide a comprehensive overview of the molecular players involved in PC cell death pathways.

Main Methods:

  • This study is a review of existing literature.
  • Analysis of scientific articles focusing on androgen signaling, apoptosis, and prostate cancer.
  • Synthesis of data on the roles of key proteins and hormones in PC progression and treatment resistance.

Main Results:

  • Androgens and their receptors are central to PC cell survival and proliferation.
  • Specific sex steroid hormones and heat-shock proteins modulate apoptosis pathways in PC cells.
  • Understanding these interactions is critical for developing strategies to overcome treatment resistance.

Conclusions:

  • Androgen signaling pathways are fundamental to prostate cancer pathogenesis and therapeutic response.
  • Targeting androgen-related mechanisms, including apoptosis induction, offers potential for novel treatment strategies.
  • Further research into these molecular interactions is essential for improving outcomes in advanced prostate cancer.