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Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

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Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Related Experiment Video

Updated: Nov 26, 2025

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
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Transcatheter Pulmonary Valve Replacement With the Sapien Prosthesis.

Shabana Shahanavaz1, Evan M Zahn2, Daniel S Levi3

  • 1Division of Cardiology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.

Journal of the American College of Cardiology
|December 11, 2020
PubMed
Summary

Transcatheter pulmonary valve replacement (TPVR) using Sapien XT or Sapien 3 valves showed excellent short-term outcomes across various right ventricular outflow tract anatomies. Further research is needed for long-term insights.

Keywords:
Sapien S3Sapien XTtetralogy of Fallot

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Surgery

Background:

  • Limited data exists on transcatheter pulmonary valve replacement (TPVR) outcomes using Sapien XT or Sapien 3 (S3) valves.
  • This study addresses the need for more information on TPVR with these specific balloon-expandable valves.

Purpose of the Study:

  • To report short-term outcomes of a large patient cohort undergoing TPVR with Sapien XT or S3 valves.
  • To analyze outcomes based on different right ventricular outflow tract (RVOT) anatomies.

Main Methods:

  • Retrospective data collection from a multicenter registry of patients who underwent attempted TPVR with Sapien XT or S3 valves.
  • Characterization of patient demographics, procedural details, and short-term outcomes, stratified by RVOT anatomy.

Main Results:

  • The study included 774 patients across 23 centers, with 78% receiving the S3 valve.
  • Technical success was high (97.4%), with serious adverse events in 10% of patients.
  • Excellent short-term valve function was observed, though 8.5% experienced moderate or greater pulmonary regurgitation or elevated gradients.

Conclusions:

  • Transcatheter pulmonary valve replacement with balloon-expandable valves demonstrates generally excellent acute outcomes in all RVOT types.
  • Longer follow-up and additional data are crucial for a comprehensive understanding of TPVR efficacy and safety.