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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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Conception after early IVF pregnancy loss: should we wait?

Maya Sharon-Weiner1, Hadar Gluska2, Sivan Farladansky-Gershenabel2

  • 1Department of Obstetrics and Gynecology, Meir Medical Center, Department of Obstetrics and Gynecology, 59 Tchernichovsky St, Kfar Saba Israel 4428164, Israel; IVF unit, Meir Medical Center, affiliated to the Sackler Faculty of Medicine, Kfar Saba, Israel.

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Summary

Waiting to restart IVF treatment after early pregnancy loss does not improve pregnancy success. Shorter intervals between miscarriage and subsequent IVF cycles are linked to a higher chance of live birth.

Keywords:
Early pregnancy lossIVFLive birthMiscarriagePregnancy interval

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Area of Science:

  • Reproductive Endocrinology
  • In Vitro Fertilization (IVF)
  • Pregnancy Loss

Background:

  • Early pregnancy loss is a common complication of In Vitro Fertilization (IVF).
  • The optimal timing for reinitiating IVF treatment after a pregnancy loss remains a clinical question.

Purpose of the Study:

  • To investigate whether the interval between an early pregnancy loss and the subsequent IVF treatment cycle predicts clinical pregnancy achievement.
  • To explore the association between the type of miscarriage and the interval to the next IVF cycle.

Main Methods:

  • Retrospective cohort study of 257 women undergoing IVF after first-trimester pregnancy loss.
  • Data collected from a tertiary medical center between January 2014 and January 2018.
  • Miscarriage types included spontaneous, biochemical, medical, and surgical; analysis used Kaplan-Meier and logistic regression.

Main Results:

  • The interval to subsequent IVF treatment was not significantly associated with achieving pregnancy.
  • Shorter intervals were observed after spontaneous or biochemical miscarriages compared to medical or surgical ones.
  • The number of embryos transferred and the type of miscarriage (medical/surgical linked to lower pregnancy likelihood) affected subsequent pregnancy chances.
  • Shorter intervals post-miscarriage were associated with increased live birth chances in the first post-miscarriage cycle.

Conclusions:

  • IVF treatment should not be postponed after pregnancy loss.
  • Shorter intervals between pregnancy loss and subsequent IVF cycles are associated with a greater likelihood of live birth.