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Updated: Nov 26, 2025

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood
Published on: January 9, 2018
Atypical presentation of anti-N-methyl-D-aspartate receptor encephalitis in a 61-year-old Hispanic man
Esme Irvine1, Debra Cheng2, Daa Xiao2
1College of Osteopathic Medicine, Touro University California, Vallejo, California, USA esme.irvine@tu.edu.
Abstract:
A 61-year-old Hispanic man with no psychiatric history presented with an acute onset of personality changes, including aggression and hypersexuality, which progressed to hallucinations and fluctuations in mental status, and was diagnosed with anti-N-methyl-D-aspartate receptor encephalitis. This report emphasises the importance of having anti-NDMA receptor encephalitis on the list of differential diagnoses in acute, unprovoked personality changes in older adults.
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