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Related Experiment Video

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WEB Device Shape Changes in Elastase-Induced Aneurysms in Rabbits.

Y Ding1, D Dai1, A Rouchaud2

  • 1From the Department of Radiology (Y.D., D.D., S.A., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota.

AJNR. American Journal of Neuroradiology
|December 11, 2020
PubMed
Summary
This summary is machine-generated.

WEB device shape modification did not correlate with incomplete aneurysm occlusion in a rabbit model. This modification may be linked to tissue healing and connective tissue formation after WEB device implantation.

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Area of Science:

  • Biomedical Engineering
  • Neurosurgery
  • Vascular Biology

Background:

  • WEB devices are utilized for aneurysm treatment, demonstrating safety and efficacy.
  • WEB-shape modification has been linked to incomplete aneurysm occlusion.
  • Understanding this relationship is crucial for optimizing treatment outcomes.

Purpose of the Study:

  • To investigate the correlation between WEB-shape modification and occlusion rates in different WEB device types.
  • To analyze the impact of WEB-shape modification on aneurysm healing and histological features.

Main Methods:

  • Elastase-induced aneurysms were created in rabbits.
  • Treatment involved dual-layer, single-layer, or single-layer sphere WEB devices.
  • Angiographic occlusion was graded using the WEB Occlusion Scale; WEB-shape modification and histology were analyzed at 3 or 12 months.

Main Results:

  • Adequate occlusion (grades I-III) was achieved in 61.1% of aneurysms.
  • WEB-shape modification occurred in 61.1% of aneurysms, being more frequent in single-layer and dual-layer devices.
  • WEB-shape modification correlated with increased thrombus organization, fibrosis, and smooth muscle cells, but not with angiographic or histological outcomes.

Conclusions:

  • WEB-shape modification is not associated with incomplete aneurysm occlusion in this experimental model.
  • The observed modification may reflect the biological response to WEB device implantation, including connective tissue formation and healing.
  • Further research is needed to fully elucidate the implications of WEB-shape modification.