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Updated: Nov 26, 2025

Generation of Size-controlled Poly ethylene Glycol Diacrylate Droplets via Semi-3-Dimensional Flow Focusing Microfluidic Devices

Generation of Size-controlled Poly ethylene Glycol Diacrylate Droplets via Semi-3-Dimensional Flow Focusing Microfluidic Devices

Published on: July 3, 2018

Microfluidic droplet generation based on non-embedded co-flow-focusing using 3D printed nozzle.

Adrien Dewandre¹, Javier Rivero-Rodriguez², Youen Vitry²

¹TIPs Lab, Université libre de Bruxelles, Brussels, 1050, Belgium. adrien.dewandre@ulb.ac.be.

Scientific Reports

|December 11, 2020

Summary

This summary is machine-generated.

A novel microfluidic droplet generator, Raydrop, utilizes axisymmetric co-flow-focusing for universal fluid handling without surfactants. This robust, scalable technology offers high-throughput potential for droplet generation processes.

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Area of Science:

Microfluidics
Fluid Dynamics
Materials Science

Background:

Commercial microfluidic droplet generators often use planar flow-focusing, requiring specific coatings or surfactants.
Planar geometry presents limitations in fluid compatibility and operational versatility.
Existing axisymmetric capillary generators are difficult to fabricate and not scalable for market entry.

Purpose of the Study:

To introduce a novel, scalable, and universally compatible microfluidic droplet generator.
To investigate the fluid dynamics and droplet formation mechanisms in an axisymmetric co-flow-focusing configuration.
To demonstrate the potential for high-throughput droplet generation without specialized additives.

Main Methods:

Development of the Raydrop device using aligned capillaries in a pressurized chamber with a 3D-printed nozzle.
Experimental emulsification of diverse fluids to assess device universality and droplet size range.
Numerical computation of Navier-Stokes equations to model droplet formation and dripping-to-jetting transitions.

Main Results:

The Raydrop device successfully generated droplets across a wide range of radii using various fluids without surfactants or coatings.
Numerical models accurately predicted droplet radius and the dripping-to-jetting transition, validating the underlying physics.
The non-embedded axisymmetric co-flow-focusing configuration demonstrated enhanced dripping regime performance.

Conclusions:

The Raydrop technology offers a universal, surfactant-free solution for microfluidic droplet generation.
Its robust fabrication and numerical optimization capabilities position it for high-throughput applications.
This device overcomes limitations of planar systems and difficult-to-assemble capillary generators.