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Related Experiment Videos

Thrombolysis and myocardial infarction.

F Rovelli1, F Mauri, A Roghi

  • 1Department of Cardiology, Niguarda Ca'Granda Hospital, Milan, Italy.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1987
PubMed
Summary

Intravenous streptokinase (SK) significantly reduces in-hospital mortality for acute myocardial infarction (AMI) patients, especially when given within one hour of symptom onset. Long-term benefits were sustained, with low adverse reactions observed.

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Area of Science:

  • Cardiology
  • Thrombolytic Therapy

Background:

  • Acute myocardial infarction (AMI) is often caused by coronary thrombus.
  • Streptokinase (SK) is a thrombolytic agent studied for AMI treatment.

Purpose of the Study:

  • To evaluate the efficacy and safety of intravenous streptokinase (SK) in patients with acute myocardial infarction (AMI).

Main Methods:

  • A large-scale randomized trial (GISSI) involving 11,712 AMI patients.
  • Administration of 1.5 million units of SK via intravenous infusion.
  • Analysis of in-hospital mortality, adverse reactions, 12-month follow-up, plasma creatine kinase (CK) levels, and reinfarction rates.

Main Results:

  • Intravenous SK reduced in-hospital mortality from 13% to 10.7% (P = 0.0002).

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  • Mortality reduction reached 47% in patients treated within 1 hour.
  • Beneficial effects on mortality persisted at 12 months; adverse reactions were low (4.7%).
  • Increased plasma creatine kinase (CK) levels observed in SK-treated patients.
  • Higher reinfarction rates noted in the SK group (7.4% vs. 4.4%).

    • Conclusions:

    • Intravenous streptokinase (SK) is effective in reducing mortality for acute myocardial infarction (AMI) patients.
    • Early treatment with SK yields the greatest mortality benefit.
    • Further research is needed for post-thrombolytic and residual stenosis management.