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Characteristics and outcomes of hemodialysis patients with COVID-19: a retrospective single center study
Yongwen Luo1, Junli Li2, Zhifen Liu3
1Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Insights
Patients undergoing hemodialysis with COVID-19 (coronavirus 19) showed a higher risk of severe outcomes. This high-risk group experienced worse prognoses and longer hospital stays, necessitating close medical monitoring.
Area of Science:
- Nephrology
- Infectious Diseases
- Critical Care Medicine
Background:
- The COVID-19 pandemic poses significant risks to individuals with comorbid conditions.
- Patients on hemodialysis are particularly vulnerable to severe outcomes from COVID-19 infection.
Purpose of the Study:
- To investigate the clinical characteristics, laboratory findings, treatments, and prognoses of hemodialysis patients diagnosed with COVID-19.
- To compare these outcomes with non-dialysis patients who contracted COVID-19.
Main Methods:
- A retrospective, single-center study was conducted involving 16 hemodialysis patients with COVID-19.
- A control group of 62 non-dialysis COVID-19 patients was established for comparison.
- Data collected included clinical features, laboratory results, treatments, and patient outcomes.
Main Results:
- Hemodialysis patients exhibited a lower incidence of fever but higher rates of comorbidities and shortness of breath.
- Significant differences in laboratory findings were observed, including lower hemoglobin, white blood cell counts, and liver enzymes, alongside elevated D-dimer and thrombin time in hemodialysis patients.
- Radiological findings such as pulmonary effusion and atelectasis were more common in hemodialysis patients, who also faced higher mortality rates and prolonged hospital stays.
Conclusions:
- Hemodialysis patients represent a high-risk group for COVID-19 due to frequent comorbidities.
- These patients are prone to prolonged hospital stays and unfavorable prognoses.
- Close monitoring and tailored management strategies are crucial for hemodialysis patients with COVID-19.
Background:
The coronavirus 19 (COVID-19) pandemic has heightened the threat to the health and lives of patients with comorbid diseases. Infection by COVID-19 is especially detrimental to patients on hemodialysis. In this study, we evaluated the clinical characteristics, laboratory findings, treatments and prognoses of hemodialysis patients with COVID-19.
Methods:
A total of 16 hemodialysis patients with COVID-19 were recruited from Wuhan Fourth Hospital from 5 February to 20 March 2020 for a retrospective, single-center study. A total of 62 non-dialysis patients with COVID-19 were the control group. We collected data on the clinical characteristics, laboratory findings, treatments, and clinical outcomes of patients affected by the virus.
Results:
Hemodialysis patients with COVID-19 had a lower incidence of fever (P = 0.001) and relatively higher incidence of pre-admission comorbidities and shortness of breath than non-dialysis patients with COVID-19 (75% vs. 61%, P = 0.467 50% vs. 33.87%, P = 0.248 ). Hemodialysis patients had lower levels of hemoglobin (P < 0.001), white blood cell counts (P = 0.015), neutrophils (P = 0.016), AST (P = 0.037), ALT (P < 0.001) and procalcitonin (P < 0.001), and higher levels of D-dimer (P < 0.001) and thrombin time (P < 0.001). Hemodialysis patients had a higher incidence of pulmonary effusion, cord-like high-density shadows, pleural thickening, and atelectasis (P < 0.05). Hemodialysis patients also had relatively higher rates of mortality and prolonged hospital stays compared with the control group.
Conclusions:
Hemodialysis patients typically present with multiple comorbidities and are considered to be a high-risk group for COVID-19 infections. Hemodialysis patients with COVID-19 may have prolonged hospital stays and unfavorable prognoses and should be closely monitored.
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