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DNA Nanostructures and DNA-Functionalized Nanoparticles for Cancer Theranostics
Fay Nicolson1,2, Akbar Ali3, Moritz F Kircher1,2,4
1Department of Imaging Dana-Farber Cancer Institute & Harvard Medical School Boston MA 02215 USA.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|December 11, 2020
Summary
DNA nanostructures and nanoparticles are versatile tools for nanotheranostics, combining diagnostics and therapy for personalized cancer treatment. Their programmability and ease of functionalization enhance drug delivery and biostability, accelerating clinical translation.
Area of Science:
- Biotechnology
- Nanotechnology
- Materials Science
Background:
- DNA's versatility and programmability have driven nanoscale material development over the past two decades.
- DNA-based nanomaterials include DNA nanostructures (DNA-NSs) and DNA-functionalized nanoparticles (DNA-NPs).
- These materials are increasingly used in nanotheranostics for personalized cancer treatments, integrating diagnostics and therapy.
Purpose of the Study:
- To review recent advancements in DNA nanostructures and nanoparticles as theranostic agents.
- To explore their application as platforms for gene and drug delivery.
- To provide a perspective on their clinical translation in oncology.
Main Methods:
- Literature review of recent progress in DNA-based nanomaterials for theranostics.
- Analysis of DNA nanostructures and nanoparticles for drug and gene delivery applications.
- Evaluation of clinical translation potential in oncology.
Main Results:
- DNA nanostructures and nanoparticles offer high biostability, biocompatibility, and drug loading capacity.
- The ease of attaching imaging and therapeutic moieties enhances their theranostic capabilities.
- Extensive application in personalized cancer treatments has been observed.
Conclusions:
- DNA-based nanomaterials show significant promise as theranostic agents for oncology.
- Their adaptability facilitates advanced drug and gene delivery systems.
- Further research and development are crucial for successful clinical translation.
