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Updated: Nov 26, 2025
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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Mini-Review: Human Microbiome and Rheumatic Diseases.
Meltem Vural1, Benoit Gilbert2, Işıl Üstün1
1Physical Medicine and Rehabilitation Clinic, University of Health Sciences, Bakırkoy Dr. Sadi Konuk Training Hospital, Istanbul, Turkey.
Frontiers in Cellular and Infection Microbiology
|December 11, 2020
Summary
The human microbiome influences immune balance and may drive autoimmune and rheumatic diseases like rheumatoid arthritis and spondyloarthropathy. This review explores microbiota
Area of Science:
- Immunology
- Microbiology
- Rheumatology
Background:
- Rheumatoid arthritis and spondyloarthropathy are prevalent inflammatory rheumatic conditions.
- The human microbiome plays a crucial role in maintaining immune homeostasis.
- Microbiota dysbiosis is increasingly implicated in the development of autoimmune disorders.
Purpose of the Study:
- To review the role of human microbiota in the pathogenesis of rheumatic diseases.
- To focus on the specific contributions of microbiota to rheumatoid arthritis and spondyloarthropathy.
Main Methods:
- Literature review of existing studies on human microbiota and rheumatic diseases.
- Analysis of research focusing on the gut, skin, and joint microbiota.
- Synthesis of evidence linking microbial composition to disease mechanisms.
Main Results:
- Specific microbial communities are associated with increased risk and severity of rheumatoid arthritis.
- Alterations in gut microbiota composition are observed in patients with spondyloarthropathy.
- The interplay between host immunity and microbial metabolites influences inflammatory pathways.
Conclusions:
- The human microbiome is a significant factor in the pathogenesis of rheumatoid arthritis and spondyloarthropathy.
- Targeting the microbiome presents a potential therapeutic strategy for inflammatory rheumatic diseases.
- Further research is needed to elucidate specific microbial targets and mechanisms.
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