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Reflux nephropathy and pregnancy.

P Jungers, P Houillier, D Forget

    Bailliere'S Clinical Obstetrics and Gynaecology
    |December 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Women with reflux nephropathy (a kidney disease) face pregnancy risks, especially with impaired renal function. Early conception before plasma creatinine exceeds 0.18 mmol/l is advised to improve outcomes for both mother and child.

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    Area of Science:

    • Nephrology
    • Obstetrics
    • Public Health

    Background:

    • Reflux nephropathy is a common renal disease in women of childbearing age.
    • Severe bilateral atrophy and persistent vesicoureteral reflux are associated with significant complications.
    • The disease often presents during pregnancy with urinary tract infections or worsening renal function.

    Purpose of the Study:

    • To evaluate the impact of reflux nephropathy on pregnancy outcomes.
    • To identify risk factors for adverse pregnancy and renal outcomes in affected women.
    • To provide guidance on conception timing for women with reflux nephropathy.

    Main Methods:

    • Review of clinical data from women with reflux nephropathy.
    • Analysis of pregnancy outcomes in relation to renal function and hypertension.

    Related Experiment Videos

  • Correlation of plasma creatinine levels at conception with maternal and fetal health.

    • Main Results:

    • Successful pregnancies are common when renal function is normal and hypertension is absent at conception.
    • Impaired renal function (creatinine > 0.18-0.20 mmol/l), especially with hypertension, significantly increases risks of fetal growth retardation, intrauterine death, and rapid progression to end-stage renal failure.
    • Urinary tract infections cause morbidity but rarely fetal mortality.

    Conclusions:

    • Women with reflux nephropathy should aim to conceive before plasma creatinine reaches 0.18 mmol/l.
    • Patients with higher creatinine levels face substantial risks for both pregnancy and disease progression.
    • Clear counseling regarding these risks is crucial for informed decision-making.