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IL-6 and other biomarkers as predictors of severity in COVID-19
N Broman1, K Rantasärkkä2, T Feuth3
1Department of Infectious Diseases, Turku University Hospital, Turku, Finland.
Objective:
Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers.
Methods:
We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order to identify markers of severe COVID-19 and need of ICU.
Results:
Patients who were eventually admitted to ICU displayed significantly higher serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin. No statistical differences were found between the groups in median levels of lymphocytes, D-dimer or ferritin.
Conclusions:
IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19.
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