Relationship between Hyperlipidemia, Cardiovascular Disease and Stroke: A Systematic Review
Aladeen Alloubani1, Refat Nimer2, Rama Samara3
1Nursing Research Unit, King Hussein Cancer Center, Amman, Jordan.
Insights
Hyperlipidemia is a significant risk factor for stroke and cardiovascular disease (CVD). Managing cholesterol levels, particularly LDL, and using lipid-lowering drugs can reduce mortality and morbidity from these conditions.
Area of Science:
- Cardiology
- Neurology
- Public Health
Background:
- Dyslipidemia is a recognized independent predictor of cardiovascular and cerebrovascular events.
- There is a growing emphasis on dyslipidemia prevention and control to mitigate the impact of stroke and myocardial infarction (MI).
Purpose of the Study:
- To evaluate hyperlipidemia as a risk factor for stroke and cardiovascular disease (CVD).
- To review past research on hyperlipidemia and CVD and suggest future directions.
Main Methods:
- A comprehensive literature search was conducted using PubMed/MEDLINE and EMBASE.
- Keywords included hyperlipidemia, risk factors, stroke, and cardiovascular disease.
- Prospective studies on hyperlipidemia as a risk factor for stroke and CVD were identified.
Main Results:
- Observational studies consistently show a positive association between LDL cholesterol and coronary heart disease incidence.
- Reducing LDL cholesterol levels can decrease the risk of vascular diseases.
- Lipid-lowering drugs, such as statins, are effective in reducing mortality and morbidity in patients with stroke and CVD.
Conclusions:
- The reviewed studies confirm hyperlipidemia as a significant risk factor for stroke.
- Hyperlipidemia is strongly correlated with cardiovascular disease in affected patients.
Background:
Globally, dyslipidemia has been shown to be an independent predictor of many cardiovascular and cerebrovascular events, which led to recent advocacy towards dyslipidemia prevention and control as a key risk factor and its prognostic significance to reduce the burden of stroke and myocardial infarction (MI).
Aims:
This study aimed to evaluate hyperlipidemia as a risk factor connected with stroke and CVD. Moreover, having identified this risk factor, the study evaluates how hyperlipidemia has been examined earlier and what can be done in the future.
Methods:
All prospective studies concerning hyperlipidemia as risk factors for stroke and CVD were identified by a search of PubMed/MEDLINE and EMBASE databases with keywords hyperlipidemia, risk factors, stroke, and cardiovascular disease.
Results:
The constant positive association between the incidence of coronary heart disease and cholesterol concentration of LDL is apparent in observational studies in different populations. Thus, the reduction of LDL cholesterol in those populations, particularly with regard to initial cholesterol concentrations, can reduce the risk of vascular diseases. However, the impact of using lipid-lowering drugs, such as statins, has been demonstrated in several studies as an important factor in decreasing the mortality and morbidity rates of patients with stroke and CVD.
Conclusion:
After reviewing all the research mentioned in this review, most studies confirmed that hyperlipidemia is a risk factor for stroke and correlated in patients with CVD.
Related Concept Videos
01:26Atherosclerosis III: Management
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:30Atherosclerosis I: Introduction
01:30Coronary Artery Disease I: Introduction
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:26Coronary Artery Disease IV: Preventive Measures