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OCT-Based Angiography and Surface Topography in Burn-Damaged Skin
Jie Lu1, Anthony J Deegan1, Yuxuan Cheng1
1Department of Bioengineering, University of Washington, Seattle, Washington, 98195.
Lasers in Surgery and Medicine
|December 11, 2020
Summary
Optical coherence tomography (OCT) can assess burn wound healing by monitoring vascular changes and skin roughness. This non-invasive imaging technique provides objective data crucial for understanding wound pathophysiology and future clinical evaluation.
Area of Science:
- Biomedical Optics
- Medical Imaging
- Wound Healing Research
Background:
- Clinical need for non-invasive, objective burn wound assessment.
- Exploring physiological basis of human wound healing.
Purpose of the Study:
- Demonstrate optical coherence tomography (OCT) potential in evaluating burn wound healing.
- Explore physiological basis of human wound healing.
Main Methods:
- Retrospective study of 7 severe burn patients.
- Used in-house clinical-prototype OCT system for imaging.
- Quantified vascular area density and surface roughness across burn zones (red, white, mixed) at two time points.
Main Results:
- OCT revealed morphological changes in burn wounds, including altered blood flow and texture.
- Vascular area density was significantly altered in red and white burn zones compared to healthy controls.
- Significant changes in vascular area density and surface roughness were observed over time in white burn zones.
Conclusions:
- OCT is clinically feasible for monitoring vascular changes and skin roughness in burn wound healing.
- OCT-derived metrics offer insights into wound healing pathophysiology.
- OCT measurements may serve as critical biological indicators for future wound monitoring.
