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Related Experiment Videos

Disopyramide-induced hypoglycaemia and increased serum insulin.

M S Croxson1, D W Shaw, P G Henley

  • 1Department of Endocrinology, Auckland Hospital.

The New Zealand Medical Journal
|July 8, 1987
PubMed
Summary

Disopyramide can cause dangerously low blood sugar (hypoglycaemia) by increasing insulin release. This effect, seen in a patient and case reports, may be linked to pneumonia mortality.

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Area of Science:

  • Pharmacology
  • Endocrinology
  • Clinical Medicine

Background:

  • Disopyramide is an antiarrhythmic medication.
  • Hypoglycaemia is a critical condition characterized by low blood glucose levels.
  • Antimalarial drugs like quinine and quinidine are known to stimulate insulin release.

Observation:

  • A patient receiving disopyramide experienced severe hypoglycaemia.
  • The patient also exhibited elevated serum insulin levels.
  • The patient ultimately succumbed to pneumonia.

Findings:

  • Disopyramide administration is associated with hypoglycaemia.
  • The mechanism proposed is the stimulation of insulin release.
  • This effect mirrors that of quinine and quinidine.

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Implications:

  • Clinicians should monitor blood glucose levels in patients treated with disopyramide.
  • Understanding this adverse effect is crucial for patient safety.
  • Further research may elucidate the link between disopyramide-induced hypoglycaemia and patient outcomes.