Double blind, randomised trial comparing single dose enoxacin and trimethoprim for treatment of bacterial cystitis

Women with acute lower urinary tract symptoms were enrolled in a randomised, double blind study and received either a single 400 mg dose of enoxacin or a single 600 mg dose of trimethoprim. Twenty of 29 women with bacterial cystitis were cured with enoxacin and 22 of 26 with trimethoprim. Both drugs were highly effective for the treatment of Escherichia coli, but enoxacin was disappointing for the eradication of Staphylococcus saprophyticus. Side effects were minimal. Single dose therapy is recommended as the treatment of choice for bacterial cystitis in general practice.