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Updated: Nov 26, 2025

Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis

Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis

Published on: March 7, 2018

Single-atom catalysts boost signal amplification for biosensing.

Lei Jiao¹, Weiqing Xu, Yu Wu

¹Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China. czzhu@mail.ccnu.edu.cn.

Chemical Society Reviews

|December 11, 2020

Summary

This summary is machine-generated.

Single-atom catalysts (SACs) enhance biosensor sensitivity and selectivity through unique atomic structures. This review details SACs

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Area of Science:

Nanomaterials
Catalysis
Biosensing

Background:

Biosensor sensitivity and selectivity require improvement.
Nanomaterials offer signal amplification in biosensing.
Single-atom catalysts (SACs) possess unique catalytic properties.

Purpose of the Study:

To review the advantages of SACs in biosensing.
To discuss the catalytic mechanisms and signal amplification effects of SACs.
To explore future opportunities and challenges for SAC-enabled biosensors.

Main Methods:

Review of literature on SACs in biosensing.
Discussion of catalytic mechanisms at the atomic scale.
Analysis of signal amplification in various biosensing platforms.

Main Results:

SACs provide enhanced catalytic activity and selectivity.
SACs demonstrate satisfactory sensitivity and selectivity in biosensing applications.
Tunable metal-support interactions, coordination environments, and active site structures contribute to SAC performance.

Conclusions:

SAC-enabled signal amplification is a promising strategy for advanced biosensors.
Further research is needed to overcome challenges and realize the full potential of SACs in biosensing.