Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

197
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
197
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

219
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
219
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

161
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
161
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

82
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
82
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

108
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
108
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.6K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Hungarian DREEM: translation, cultural adaptation, and psychometric validation of the learning environment questionnaire for medical and health professions education.

Frontiers in medicine·2026
Same author

3D virtual histopathology of human breast tissues using an X-ray grating interferometry micro CT system.

Experimental and molecular pathology·2026
Same author

Margin Adequacy in Phyllodes Tumours Revisited: Reappraisal of the Evidence Base and Knowledge Gaps.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
Same author

Thalamic activation of the visual cortex at the single-synapse level.

Science (New York, N.Y.)·2026
Same author

Integrated Histology and Molecular Profiling of Postmortem Human Auditory and Vestibular Organs via a Poly (Methyl Methacrylate)-Based Workflow.

Journal of the Association for Research in Otolaryngology : JARO·2026
Same author

Effectiveness of exercise interventions on androgen and sex hormone-binding globulin levels in women with polycystic ovary syndrome: a systematic review and meta-analysis.

Frontiers in sports and active living·2026
Same journal

[Connective (tissue) pathology: What brings us together!]

Der Pathologe·2022
Same journal

[Giant cell-containing tumors of bone and differential diagnoses].

Der Pathologe·2022
Same journal

[Automation and application of robotics in the pathology laboratory].

Der Pathologe·2022
Same journal

[Practical diagnostic aspects of uterine leiomyosarcoma in the context of the 2020 WHO classification].

Der Pathologe·2022
Same journal

[Artificial intelligence: a solution for the lack of pathologists?]

Der Pathologe·2022
Same journal

[Predictive immunocytochemistry in non-small cell lung carcinoma].

Der Pathologe·2022
See all related articles

Related Experiment Video

Updated: Nov 26, 2025

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
06:29

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19

Published on: May 25, 2022

2.6K

[Endotheliitis in COVID-19].

Zsuzsanna Varga1

  • 1Institut für Pathologie und Molekularpathologie, Universitätsspital Zürich, Schmelzbergstraße 12, CH-8091, Zürich, Schweiz. zsuzsanna.varga@usz.ch.

Der Pathologe
|December 11, 2020
PubMed
Summary
This summary is machine-generated.

COVID-19 causes systemic inflammation, leading to endotheliitis (endothelial inflammation). Pre-existing endothelial dysfunction significantly increases the risk of severe COVID-19 outcomes.

Keywords:
COVID-19Diffuse organ affectionEndotheliitisSARS-CoV-2

More Related Videos

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

609
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.5K

Related Experiment Videos

Last Updated: Nov 26, 2025

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
06:29

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19

Published on: May 25, 2022

2.6K
Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

609
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.5K

Area of Science:

  • Cardiovascular Science
  • Infectious Diseases
  • Pathology

Background:

  • COVID-19 presents as a viral and inflammatory phase, with the latter carrying high mortality.
  • Cardiovascular diseases and risk factors elevate the risk of severe COVID-19.
  • COVID-19 targets lung epithelial cells and systemic endothelial cells, causing endotheliitis.

Purpose of the Study:

  • To elucidate the role of endothelial dysfunction in COVID-19 pathogenesis.
  • To highlight the vulnerability of patients with pre-existing endothelial dysfunction to severe COVID-19.
  • To provide a rationale for endothelial stabilization therapies in COVID-19.

Main Methods:

  • Autopsy-based histological analysis of affected tissues.
  • Review of clinical data linking pre-existing conditions to COVID-19 severity.
  • Pathophysiological examination of viral impact on endothelial cells.

Main Results:

  • Endotheliitis, characterized by inflammatory cell infiltration, is a key feature of severe COVID-19.
  • Endothelial damage promotes vasoconstriction, ischemia, inflammation, and a procoagulant state.
  • Patients with male sex, smoking, hypertension, diabetes, obesity, and cardiovascular disease exhibit higher vulnerability and adverse outcomes.

Conclusions:

  • Endothelial dysfunction is a critical factor in COVID-19 severity and mortality.
  • Targeting endothelial stabilization may mitigate adverse COVID-19 outcomes.
  • Understanding endotheliitis is crucial for managing high-risk patient populations.