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Related Experiment Video

Updated: Nov 26, 2025

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
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Improving povidone-iodine and iodine preparations for patch testing.

Susann Forkel1, Caroline Beutner1, Katharina Amschler1

  • 1Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.

Contact Dermatitis
|December 11, 2020
PubMed
Summary
This summary is machine-generated.

Povidone-iodine (PVP-I) 2% aqueous solution is the optimal patch test preparation for evaluating iodine allergy. Most positive patch tests are irritant reactions, not true allergies, necessitating further testing.

Keywords:
antisepticscontact hypersensitivityiodinepovidone-iodine

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Area of Science:

  • Dermatology
  • Allergology
  • Contact Dermatitis

Background:

  • Patch testing for povidone-iodine (PVP-I) and iodine allergy is challenging due to frequent false-positive and irritant reactions.
  • Current patch test preparations often yield unreliable results in allergy evaluations.

Purpose of the Study:

  • To evaluate various iodine patch test preparations.
  • To assess the clinical relevance of these preparations using repeated open application tests (ROATs).

Main Methods:

  • Retrospective analysis of 95 patients with suspected disinfectant allergy.
  • Parallel patch testing with four iodine preparations: PVP-I 2%, 5%, 10% aqueous solutions, and 0.5% iodine in petrolatum.
  • Confirmation of positive reactions via ROATs.

Main Results:

  • 28.4% of patients showed positive patch test reactions to at least one preparation.
  • Only one patient was confirmed to have iodine allergy after ROATs.
  • 32.6% of patients exhibited irritant or questionable reactions; PVP-I 2% aq. showed the fewest doubtful reactions and identified the single allergic patient.

Conclusions:

  • Povidone-iodine 2% aqueous solution is the preferred patch test preparation for iodine.
  • Iodine allergy is likely overestimated; positive patch tests require ROAT confirmation to avoid misdiagnosis.