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Updated: Jul 10, 2026

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Segmenting OCT for detecting drug efficacy in CRAO.

Thomas R Shearer¹, Thomas S Hwang², Peter N Steinkamp²

¹Department of Integrative Biomedical & Diagnostic Sciences, Oregon Health & Science University, Portland, OR, United States of America.

|December 11, 2020

Summary

Retinal thinning in central retinal artery occlusion (CRAO) patients can be modeled using optical coherence tomography (OCT) to predict clinical trial needs. Ganglion cell layer (GCL) thickness changes offer a practical marker for evaluating potential CRAO inhibitors.

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Doppler Optical Coherence Tomography of Retinal Circulation

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Published on: September 18, 2012

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

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Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

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Published on: February 18, 2022

Area of Science:

Ophthalmology
Retinal Diseases
Pharmacology

Background:

Central retinal artery occlusion (CRAO) causes inner retinal thinning.
Proteolysis by calpain may contribute to retinal thinning in CRAO.
Calpain inhibitors have shown promise in preclinical models.

Purpose of the Study:

To mathematically model retinal layer loss in CRAO patients using OCT segmentation analysis.
To predict patient numbers and observation duration for clinical trials of CRAO inhibitors.

Main Methods:

Retrospective case-control study using OHSU Epic patient data.
Computer-aided search for CRAO cases with OCT procedures.
Segmentation analysis of OCT images to model retinal layer thinning.

Main Results:

Inner retinal thinning, particularly in the ganglion cell layer (GCL), follows exponential decay.
A 30-day clinical trial could detect a 20% effect with 19 eyes/group using GCL thickness.
Whole retinal thickness and combined inner layers are less specific markers.

Conclusions:

Monitoring GCL thickness changes is a practical approach for human trials of CRAO inhibitors.
GCL thickness serves as a useful indicator of CRAO progression in clinical trials.