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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
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Determinants of Optical Coherence Tomography Parameters in a Population-based Study.
S Ramyashri1, Harsha L Rao2, Ganesh Babu Jonnadula3
1VST Centre for Glaucoma, L V Prasad Eye Institute, Hyderabad, India.
American Journal of Ophthalmology
|December 11, 2020
Summary
Optical coherence tomography (OCT) parameters like retinal nerve fiber layer (RNFL) thickness are influenced by age, sex, axial length (AXL), disc area, and scan signal strength in normal adults. These factors are crucial for interpreting OCT scans in glaucoma.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Research
Background:
- Optical coherence tomography (OCT) is vital for assessing retinal structures.
- Understanding normative OCT parameter variations is essential for diagnosing ocular conditions like glaucoma.
- The L V Prasad Eye Institute-Glaucoma Epidemiological and Molecular Genetic Study (LVPEI-GLEAMS) provides a population-based dataset for such investigations.
Purpose of the Study:
- To investigate the influence of demographic and ocular factors on OCT parameters in a normal adult population.
- To identify key variables affecting measurements of retinal nerve fiber layer (RNFL) thickness, rim area, and ganglion cell-inner plexiform layer (GC-IPL) thickness.
- To establish normative data for OCT parameters within the LVPEI-GLEAMS cohort.
Main Methods:
- A cross-sectional study involving 1,100 normal adults (aged 40-80 years) from the LVPEI-GLEAMS.
- Spectral-domain OCT (SDOCT) was used for macular and optic nerve head imaging.
- Univariate and multivariate regression models analyzed the effects of age, sex, intraocular pressure (IOP), central corneal thickness (CCT), axial length (AXL), disc area, and OCT signal strength on RNFL, rim area, and GC-IPL thickness.
Main Results:
- Mean rim area was 1.31 mm², RNFL thickness 93.7 μm, and GC-IPL thickness 79.6 μm.
- Age showed a negative association with RNFL and GC-IPL thickness (P < .001).
- Female sex, longer AXL, larger disc area, and higher OCT signal strength were significantly associated with specific OCT parameter variations (P < .001).
Conclusions:
- Age, sex, AXL, disc area, and OCT signal strength significantly impact OCT measurements in normal individuals.
- These factors must be considered when interpreting OCT parameters, especially in the context of glaucoma and other pathological conditions.
- The findings contribute to a better understanding of normative OCT variations and their clinical relevance.
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