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Published on: September 1, 2015
Study on the Mechanism Responsible for the Incompatibility of Enalapril Maleate with Sodium Starch Glycolate
Merel Rachel Bout1, Herman Vromans2
1Research and Development Department, Tiofarma B.V., Hermanus Boerhaavestraat 1, 3261 ME Oud-Beijerland, the Netherlands.
Abstract:
Enalapril maleate (EM) is known to suffer from incompatibilities in the solid state. This study investigates the destabilizing effect of sodium starch glycolate (SSG) on EM. This was done by varying the mixing ratio and moisture content of binary mixtures. Differential scanning calorimetry and microscopy show a loss of crystallinity of EM at the contact surface with SSG. It is shown that this is followed by decomposition of E to diketopiperazine (DKP). These phenomena are modulated by moisture. The environmental pH turned out to be crucial; when the zwitterion is formed at the appropriate pH, ring closure into DKP is promoted.
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