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Related Concept Videos

Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

990
In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
990

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Updated: Nov 26, 2025

Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
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A pregnancy-specific reference interval for procalcitonin.

Samuel Dockree1, Jennifer Brook2, Tim James2

  • 1Women's Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 11, 2020
PubMed
Summary
This summary is machine-generated.

Procalcitonin (PCT) levels in pregnant women are similar to non-pregnant individuals, establishing a new reference interval. This finding supports using PCT for diagnosing sepsis in pregnancy and guiding antibiotic treatment.

Keywords:
InfectionPregnancyProcalcitoninRangeReference intervalSepsis

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Area of Science:

  • Maternal Health
  • Infectious Disease Diagnostics
  • Biomarker Research

Background:

  • Sepsis significantly contributes to maternal mortality, necessitating accurate diagnostic tools.
  • Current inflammatory markers lack specificity, complicating infection diagnosis in pregnancy.
  • Procalcitonin (PCT) aids bacterial sepsis diagnosis, crucial during pregnancy, especially with COVID-19 risks.

Purpose of the Study:

  • To establish a pregnancy-specific reference interval for procalcitonin (PCT).
  • To determine if physiological changes in pregnancy affect PCT levels.
  • To inform the clinical utility of PCT in diagnosing sepsis in pregnant women.

Main Methods:

  • A cross-sectional study involving 323 healthy pregnant women.
  • Longitudinal blood sampling was conducted across all trimesters of pregnancy.
  • Analysis focused on establishing the upper reference limit for PCT.

Main Results:

  • The upper reference limit for PCT in pregnancy was determined to be 0.05 ng/mL.
  • PCT levels showed no significant variation across different gestational ages, BMI, maternal age, or fetal sex.
  • Findings indicate PCT levels are comparable between pregnant and non-pregnant populations.

Conclusions:

  • Normal physiological changes during pregnancy do not materially alter procalcitonin (PCT) levels.
  • Pregnancy status should not prevent the use of PCT for suspected sepsis diagnosis.
  • PCT can be reliably used to guide antibiotic therapy for bacterial infections at any stage of pregnancy.